Biography:

Vikas Leelavati Balasaheb Jadhav has completed PostGraduation in Radiology in 1994. He has a 23 Years of experience in the field of Gastro-Intestinal Tract Ultrasound & Diagnostic as well Therapeutic Interventional Sonography. He is the Pioneer of Gastro-Intestinal Tract Sonography, especially Gastro-Duodenal Sonography. He has delivered many Guest Lectures in Indian as well International Conferences in nearly 27 countries as an Invited Guest Faculty, since March 2000. He is a Consultant Radiologist & the Specialist in Conventional as well Unconventional Gastro-Intestinal Tract Ultrasound & Diagnostic as well Therapeutic Interventional Sonologist in Pune, India.

Abstract:

Transabdominal Sonography of the Small & Large Intestines can reveal following diseases. Bacterial & Viral Entero-Colitis. An Ulcer, whether it is superficial, deep with risk of impending perforation, Perforated, Sealed perforation, Chronic Ulcer & Post-Healing fibrosis & stricture. Polyps & Diverticulum. Benign intra-mural tumours. Intra-mural haematoma. Intestinal Ascariasis. Foreign Body. Necrotizing Entero-Colitis. Tuberculosis. Intussusception. Inflammatory Bowel Disease, Ulcerative Colitis, Cronhs Disease. Complications of an Inflammatory Bowel Disease – Perforation, Stricture. Neoplastic lesion is usually a segment involvement, & shows irregularly thickened, hypoechoic & aperistaltic wall with loss of normal layering pattern. It is usually a solitary stricture & has eccentric irregular luminal narrowing. It shows loss of normal Gut Signature. Enlargement of the involved segment seen. Shouldering effect at the ends of stricture is most common feature. Primary arising from wall itself & secondary are invasion from adjacent malignancy or distant metastasis. All these cases are compared & proved with gold standards like surgery & endoscopy. Some extra efforts taken during all routine or emergent ultrasonography examinations can be an effective non-invasive method to diagnose primarily hitherto unsuspected benign & malignant Gastro-Intestinal Tract lesions, so should be the investigation of choice.

Biography:

Céline Tiffon has completed her PhD in Tumor Biology from the University of Bern in 2007 and Postdoctoral studies from the United Kingdom and France where she has been working since 2010.

Abstract:

Pancreatic ductal adenocarcinoma, the most common subtype of human pancreatic cancer, affects both men and women and is highly aggressive, with a five-year survival rate of only about 5%. N-myc Downstream-Regulated Gene-1 (NDRG1) is a hypoxia-inducible and differentiation-related protein and candidate biomarker in pancreatic cancer. As NDRG1 expression is lost in high-grade tumors, the effects of the differentiating histone deacetylase inhibitor trichostatin A (TSA) were examined in human pancreatic cancer cell lines representing different tumor grades. Panc-1 (poorly differentiated) and Capan-1 (moderately- to well-differentiated) cells were treated with TSA. Effects were assessed in vitro by microscopic analysis, colorimetric assays, cell counts, real-time polymerase chain reaction, and western blotting. Treatment of Panc-1 cells over four days with 0.5 µM TSA restored cellular differentiation, inhibited proliferation, and enhanced p21^Cip1 protein expression. TSA upregulated NDRG1 mRNA and protein levels under normoxia from day one and by six-fold by day four (p<0.01 at all-time points). After 24 h under hypoxia, NDRG1 expression was further increased in differentiated cells (p<0.01). Favorable changes were identified in the expression of other hypoxia-regulated genes. HDAC inhibitors offer a potential novel epi-drug approach for pancreatic cancer by reversing the undifferentiated phenotype and allowing patients to overcome resistance and better respond to conventional cytotoxic treatments. Restoration of NDRG1 expression may represent a biomarker of malignant pancreatic tumors undergoing re-differentiation and redirecting toward a lower tumor grade. The use of the human ductal Panc-1 cell line treated with TSA represents a useful tool to study cellular differentiation through epigenetic mechanisms.

Biography:

Derouiche Abdelfettah has received a PhD in Bio-industry from the University of Nancy France in 1988 and PhD in Human Nutrition in 2008, Hassan University II Casablanca Morocco. He is the Professor in Human Nutrition and is a Director of the human nutrition research unit. He is a Temporary adviser on nutrition of WHO and the Head of Moroccan action on salt and health (MASH).

Abstract:

Statement of the Problem: Non-communicable diseases (NCDs) are not just a public health problem, they are also economical. These diseases are accentuated in the part of the population facing economic challenges and often resulting from rural exodus. The results of the (NCD) screenings in the city of Casablanca Morocco showed a high frequency of obesity and possible undiagnosed cases of NCD in low and middle-income areas. This study aimed to evaluate the prevalence of obesity among women in Casablanca and to study the factors involved.

Method: A survey was conducted in six Casablanca neighborhoods using multi-stage cluster sampling. Anthropometric parameters and body composition were measured and information on the evolution of eating habits, socio-demographic status and body image perception and use of fattening products was collected using a questionnaire of 425 adult women from the neighborhoods of Casablanca.

Result: We found a prevalence of 47% obesity and 36% overweight. Obesity and overweight exceeded 80% in all age groups, except for women under 25, where we found a prevalence of 44% overweight. In addition, the prevalence of abdominal obesity was high in all age groups with an overall prevalence of 67%. Body image perception data showed that 62% of women perceived their weight as normal or insufficient, 46% of these women were, in fact, overweight or obese. Fattening products have been used at least once by 12% of the population, especially by women under 35 years of age.

Conclusion: The problem of overweight and obesity in this society exceeds twice the national prevalence it would be in addition to the change in eating behavior and lifestyle to the perception of a regular weight and the use of fattening substances.

Biography:

Yerimova N Zh, Gastroenterologist of  Syzganov’s  National Scientific Center of  Surgery. Her research interest includes Gastroenterology, children liver transplantation and general pediatrics, scientific research, stem cell.

Abstract:

Aim: Evaluation of the effectiveness of the prevention of the treatment of cytomegalovirus infection after liver transplantation in children under 1 year of age with biliary atresia.

Material & Methods: Since March 2016 18 liver transplants from a living related donor in children were performed. The age of the patients ranged from 7 months to 8 years. Of these 15 (83.3%) patients were with biliary atresia. The number of girls is 10 (66.7%) and boys 5 (33.3%). At the time of diagnosis, most of the children registered formed cirrhosis of the liver.

Results: All recipients with positive quantitative parameters of PCR received CMV-specific immunoglobulin 3-5 months before the operation. The left lateral sector was transplanted to 15 patients with biliary atresia from CMV of the seropositive related lifelong donor (D+/R+) 13 donors and from CMV 1 seronegative donor (D-/R+), 1 to the simultaneous transplantation (liver and kidney) 2 patients with cirrhosis of the liver in the outcome of autoimmune hepatitis. In all children, biliary atresia was combined with a cytomegalovirus infection, 7 of them with an active form. The observation period is from 14 days after the operation to 2 years. After the operation, a three-component immunosuppressive therapy was performed (prednisolone, Sellsept, Tacrolimus). Activation was noted in 2 patients with inactive form of CMV. In 2 children, neurologic symptoms developed - 1 with active form of CMV and in 1 child it was associated with a toxic effect of immunosuppressive therapy (tacrolimus), which was managed by conservative methods of treatment. All children with cytomegalovirus infection received antiviral therapy with valganciclovir at a rate of 18 mg/kg for 1 month, against which the virus load in children with an active CMV phase was reduced. Six months after the operation, in all children, the quality of PCR for CMV was negative. At 9 months after liver transplantation, 1 patient with an inactive form of CMV had an increase in viral load.

Conclusions: Thus, our experience once again confirms the role of cytomegalovirus infection in the development of biliary atresia with the formation of liver cirrhosis and requires adequate follow-up after liver transplantation.

Biography:

Jessica Danaher has completed her PhD at Victoria University in Human Obesity Genetics and Skeletal Muscle Metabolism using nutrition and exercise stressors. She also pursued Masters of Dietetics at Deakin University and is now an Accredited Practicing Dietitian. Her previous roles include Clinical Dietitian at St Vincent's Hospital, Casual Research Fellow at Deakin University, Sessional Academic at Victoria University and Victorian Clinical Director of Health Promotion for Special Olympics Australia. She is currently a Lecturer/Early Career Development Fellow in Nutrition at RMIT University.

Abstract:

Since the human genome has been sequenced there has been a revolution in our understanding of how genetic variation can considerably influence medical outcomes and responses to therapeutic interventions. Advancements in this field have been particularly prominent in the field of oncology, where developing tailored drug-based interventions for specific genetic alterations has led to remarkable therapeutic outcomes. The genomic revolution represents the next shift in how we treat people for various diseases by specifically tailoring their treatment based on their genetic background, including how diet affects our health. Not all people respond in the same way to different food and food patterns. This is influenced by an individual’s genetic make-up. Personalized nutrition recommendations by health professionals, which take genetic differences into account, will therefore become necessary to prevent and treat nutrition-related diseases, in contrast to conventional one-size-fits all recommendations. The ability to provide a person dietary advice, specific to their genetic make-up, is also complicated by other factors. This includes how environmental factors modify genes (epigenetics), the composition of good and bad bacteria (microbiome) in the gut and the levels of different metabolites in the blood. These factors together describe nutritional genomics and all must be taken into consideration when identifying genetic sub-groups who would benefit from particular dietary recommendations. The ultimate goal in this field is to integrate all of this information to ensure that health-care professionals, including nutritionist’s and dietitians, know enough about nutritional genomics to decide on the most appropriate level of care to achieve personalized nutrition. This presentation will discuss the adoption of nutritional genomics technologies in nutrition practice, focusing on current evidence, barriers and future directions.

Biography:

Abstract:

Biography:

Vikas Leelavati Balasaheb Jadhav has completed PostGraduation in Radiology in 1994. He has a 23 Years of experience in the field of Gastro-Intestinal Tract Ultrasound & Diagnostic as well Therapeutic Interventional Sonography. He is the Pioneer of Gastro-Intestinal Tract Sonography, especially Gastro-Duodenal Sonography. He has delivered many Guest Lectures in Indian as well International Conferences in nearly 27 countries as an Invited Guest Faculty, since March 2000. He is a Consultant Radiologist & the Specialist in Conventional as well Unconventional Gastro-Intestinal Tract Ultrasound & Diagnostic as well Therapeutic Interventional Sonologist in Pune, India.

Abstract:

Transabdominal Sonography of the Small & Large Intestines can reveal following diseases. Bacterial & Viral Entero-Colitis. An Ulcer, whether it is superficial, deep with risk of impending perforation, Perforated, Sealed perforation, Chronic Ulcer & Post-Healing fibrosis & stricture. Polyps & Diverticulum. Benign intra-mural tumours. Intra-mural haematoma. Intestinal Ascariasis. Foreign Body. Necrotizing Entero-Colitis. Tuberculosis. Intussusception. Inflammatory Bowel Disease, Ulcerative Colitis, Cronhs Disease. Complications of an Inflammatory Bowel Disease – Perforation, Stricture. Neoplastic lesion is usually a segment involvement, & shows irregularly thickened, hypoechoic & aperistaltic wall with loss of normal layering pattern. It is usually a solitary stricture & has eccentric irregular luminal narrowing. It shows loss of normal Gut Signature. Enlargement of the involved segment seen. Shouldering effect at the ends of stricture is most common feature. Primary arising from wall itself & secondary are invasion from adjacent malignancy or distant metastasis. All these cases are compared & proved with gold standards like surgery & endoscopy. Some extra efforts taken during all routine or emergent ultrasonography examinations can be an effective non-invasive method to diagnose primarily hitherto unsuspected benign & malignant Gastro-Intestinal Tract lesions, so should be the investigation of choice.

Biography:

Yerimova N Zh, Gastroenterologist of  Syzganov’s  National Scientific Center of  Surgery. Her research interest includes Gastroenterology, children liver transplantation and general pediatrics, scientific research, stem cell.

Abstract:

Aim: Evaluation of the effectiveness of the prevention of the treatment of cytomegalovirus infection after liver transplantation in children under 1 year of age with biliary atresia.

Material & Methods: Since March 2016 18 liver transplants from a living related donor in children were performed. The age of the patients ranged from 7 months to 8 years. Of these 15 (83.3%) patients were with biliary atresia. The number of girls is 10 (66.7%) and boys 5 (33.3%). At the time of diagnosis, most of the children registered formed cirrhosis of the liver.

Results: All recipients with positive quantitative parameters of PCR received CMV-specific immunoglobulin 3-5 months before the operation. The left lateral sector was transplanted to 15 patients with biliary atresia from CMV of the seropositive related lifelong donor (D+/R+) 13 donors and from CMV 1 seronegative donor (D-/R+), 1 to the simultaneous transplantation (liver and kidney) 2 patients with cirrhosis of the liver in the outcome of autoimmune hepatitis. In all children, biliary atresia was combined with a cytomegalovirus infection, 7 of them with an active form. The observation period is from 14 days after the operation to 2 years. After the operation, a three-component immunosuppressive therapy was performed (prednisolone, Sellsept, Tacrolimus). Activation was noted in 2 patients with inactive form of CMV. In 2 children, neurologic symptoms developed - 1 with active form of CMV and in 1 child it was associated with a toxic effect of immunosuppressive therapy (tacrolimus), which was managed by conservative methods of treatment. All children with cytomegalovirus infection received antiviral therapy with valganciclovir at a rate of 18 mg/kg for 1 month, against which the virus load in children with an active CMV phase was reduced. Six months after the operation, in all children, the quality of PCR for CMV was negative. At 9 months after liver transplantation, 1 patient with an inactive form of CMV had an increase in viral load.

Conclusions: Thus, our experience once again confirms the role of cytomegalovirus infection in the development of biliary atresia with the formation of liver cirrhosis and requires adequate follow-up after liver transplantation.

Biography:

Derouiche Abdelfettah has received a PhD in Bio-industry from the University of Nancy France in 1988 and PhD in Human Nutrition in 2008, Hassan University II Casablanca Morocco. He is the Professor in Human Nutrition and is a Director of the human nutrition research unit. He is a Temporary adviser on nutrition of WHO and the Head of Moroccan action on salt and health (MASH).

Abstract:

Statement of the Problem: Non-communicable diseases (NCDs) are not just a public health problem, they are also economical. These diseases are accentuated in the part of the population facing economic challenges and often resulting from rural exodus. The results of the (NCD) screenings in the city of Casablanca Morocco showed a high frequency of obesity and possible undiagnosed cases of NCD in low and middle-income areas. This study aimed to evaluate the prevalence of obesity among women in Casablanca and to study the factors involved.

Method: A survey was conducted in six Casablanca neighborhoods using multi-stage cluster sampling. Anthropometric parameters and body composition were measured and information on the evolution of eating habits, socio-demographic status and body image perception and use of fattening products was collected using a questionnaire of 425 adult women from the neighborhoods of Casablanca.

Result: We found a prevalence of 47% obesity and 36% overweight. Obesity and overweight exceeded 80% in all age groups, except for women under 25, where we found a prevalence of 44% overweight. In addition, the prevalence of abdominal obesity was high in all age groups with an overall prevalence of 67%. Body image perception data showed that 62% of women perceived their weight as normal or insufficient, 46% of these women were, in fact, overweight or obese. Fattening products have been used at least once by 12% of the population, especially by women under 35 years of age.

Conclusion: The problem of overweight and obesity in this society exceeds twice the national prevalence it would be in addition to the change in eating behavior and lifestyle to the perception of a regular weight and the use of fattening substances.

Biography:

Abstract:

Biography:

Abstract:

Biography:

Yerimova N Zh, Gastroenterologist of  Syzganov’s  National Scientific Center of  Surgery. Her research interest includes Gastroenterology, children liver transplantation and general pediatrics, scientific research, stem cell.

Abstract:

Aim: Evaluation of the effectiveness of the prevention of the treatment of cytomegalovirus infection after liver transplantation in children under 1 year of age with biliary atresia.

Material & Methods: Since March 2016 18 liver transplants from a living related donor in children were performed. The age of the patients ranged from 7 months to 8 years. Of these 15 (83.3%) patients were with biliary atresia. The number of girls is 10 (66.7%) and boys 5 (33.3%). At the time of diagnosis, most of the children registered formed cirrhosis of the liver.

Results: All recipients with positive quantitative parameters of PCR received CMV-specific immunoglobulin 3-5 months before the operation. The left lateral sector was transplanted to 15 patients with biliary atresia from CMV of the seropositive related lifelong donor (D+/R+) 13 donors and from CMV 1 seronegative donor (D-/R+), 1 to the simultaneous transplantation (liver and kidney) 2 patients with cirrhosis of the liver in the outcome of autoimmune hepatitis. In all children, biliary atresia was combined with a cytomegalovirus infection, 7 of them with an active form. The observation period is from 14 days after the operation to 2 years. After the operation, a three-component immunosuppressive therapy was performed (prednisolone, Sellsept, Tacrolimus). Activation was noted in 2 patients with inactive form of CMV. In 2 children, neurologic symptoms developed - 1 with active form of CMV and in 1 child it was associated with a toxic effect of immunosuppressive therapy (tacrolimus), which was managed by conservative methods of treatment. All children with cytomegalovirus infection received antiviral therapy with valganciclovir at a rate of 18 mg/kg for 1 month, against which the virus load in children with an active CMV phase was reduced. Six months after the operation, in all children, the quality of PCR for CMV was negative. At 9 months after liver transplantation, 1 patient with an inactive form of CMV had an increase in viral load.

Conclusions: Thus, our experience once again confirms the role of cytomegalovirus infection in the development of biliary atresia with the formation of liver cirrhosis and requires adequate follow-up after liver transplantation.